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Crosstalk between 5-methylcytosine and N6-methyladenosine machinery defines disease progression, therapeutic response and pharmacogenomic landscape in hepatocellular carcinoma.
Tian Y, Xiao H, Yang Y, Zhang P, Yuan J, Zhang W, Chen L, Fan Y, Zhang J, Cheng H, Deng T, Yang L, Wang W, Chen G, Wang P, Gong P, Niu X, Zhang X. Tian Y, et al. Mol Cancer. 2023 Jan 10;22(1):5. doi: 10.1186/s12943-022-01706-6. Mol Cancer. 2023. PMID: 36627693 Free PMC article.
Finally, we determined potential therapeutic compounds and druggable targets (TUBB1 and P2RY4) for HCC patients with high EME. CONCLUSIONS: Our findings suggest that HCC may result from a unique synergistic combination of 5mC-epigenetic mechanism mixed with m(6)A-epitransc …
Finally, we determined potential therapeutic compounds and druggable targets (TUBB1 and P2RY4) for HCC patients with high EME. CONCLU …
TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia.
Kunishima S, Nishimura S, Suzuki H, Imaizumi M, Saito H. Kunishima S, et al. Eur J Haematol. 2014 Apr;92(4):276-82. doi: 10.1111/ejh.12252. Epub 2014 Jan 11. Eur J Haematol. 2014. PMID: 24344610
This report describes a family with TUBB1-associated macrothrombocytopenia diagnosed based on abnormal platelet beta1-tubulin distribution. A circumferential marginal microtubule band was undetectable, whereas microtubules were frayed and disorganized in every platelet fro …
This report describes a family with TUBB1-associated macrothrombocytopenia diagnosed based on abnormal platelet beta1-tubulin distrib …
Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism.
Hundhausen C, Boesch-Saadatmandi C, Matzner N, Lang F, Blank R, Wolffram S, Blaschek W, Rimbach G. Hundhausen C, et al. Cancer Genomics Proteomics. 2008 Nov-Dec;5(6):319-32. Cancer Genomics Proteomics. 2008. PMID: 19287073 Free article.
Although recent studies have indicated that OTA modulates renal gene expression, little is known regarding its impact on differential gene expression in the liver. Therefore a microarray study of the HepG2 liver cell transcriptome in response to OTA exposure (0, 0.2 …
Although recent studies have indicated that OTA modulates renal gene expression, little is known regarding its impact on differential gene e …